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The immunoconjugate of claim 33, wherein the drug comprises a pyrrolobenzodiazepine or a pyrrolobenzodiazepine dimer

LRRK2 G2019S mutation increases pathological kinase activity.Bottom (esculetin intervention):ESC exhibits multi-target effects (green/blue arrows): enzyme inhibition (AChE IC = 6.13 M

3d,e and Supplementary Table 3)

Proanthocyanidins from grape seeds inhibit UVradiation-induced immune suppression in mice: detection and analysis of molecular and cellular targets

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The ratio of HP [1- 13 C]glycine to -glutamyl-[1- 13 C]glycine evaluated in the same ROIs was higher in tumor compared to normal-appearing brain (0.33 0.03 a.u